[PubMed], Except where otherwise noted, this work is licensed under Patients in drug group were younger than placebo group but clinically it may not important because they were similar in other symptoms or signs and covariance analysis according to age showed that an improvement in drug group was significantly consistent. E. angustifolia (whole seeds) and ginger (rhizomes) were authenticated by Dr. B. Eslami (assistant professor of plant systematic) and the voucher specimens were deposited (Nos. 2012; 95 Suppl 1 : S59 There are some trials about the efficacy of ginger extract [4, 5, 9] or E. angustifolia in [3] in OA but we tried to evaluate the efficacy and safety of combining ginger and E. angustifolia extracts in knee osteoarthritis. (2011) have investigated effect of different doses of E. angustifolia water extract with and without morphine on analgesic ratio in rats. Osteoarthritis Cartilage. [DOI][PubMed], Chrubasik JE, Roufogalis BD, Chrubasik S. Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain. The authors would also like to thank Bahman Eslami for authenticating the plants scientific names. All Rights Reserved. 2 The level of significance was assumed 0.05. The classic criteria method for OA of the knee is based upon the presence of knee pain plus at least 3 of the following 6 clinical characteristics: greater than 50 years of age, morning stiffness for less than 30 minutes, crepitus on active motion of the knee, bony tenderness, bony enlargement and no palpable warmth [14]. Rabiei 4). PDF | Objective Postmenopausal osteoporosis is characterized by increased fracture risk. Zahedan Journal of Research in Medical Sciences, The Official Journal of Zahedan University of Medical Sciences. Preparation of Elaeagnus angustifolia extract: About 200 g of fresh E. angustifolia fruit were dried under ambient temperature and the dried fruits were milled. Edible extract 300 mg and 20% gel had lesser effects. The authors concluded that one month duration of therapy with only one dose of ginger extract application might not have been adequate for all the effects of ginger extract to be detected [9]. Antioxidants have an essential role in protecting tissues from oxidative damages and … 2007; 12(1) : 49 Zahedan J Res Med Sci. [PubMed], Zitzer SF, Dawson JO. Thus, we herein investigated the effects of the aqueous EA extract … Background: Patients were excluded if they were pregnant or lactating, if their disorder was secondary to inflammatory arthritis, or with uncontrolled hypertension (blood pressure ˃ 140/90), heart failure (class 3 or 4), renal failure (serum creatinine ˃ 1.5), liver dysfunction (liver enzyme ˃ 1.5 times more than normal), raised ESR (according age and sex), history of peptic disease or bronchospasm, and cerebral vascular accident or myocardial infarction in past year. Several experimental studies have used herbal extracts for treatment of the inflammatory bowel diseases. Conclusions: In this study, Elaeagnus angustifolia fruit extract (EAFE), a natural plant extract, was examined for its antioxidant activity against CP-induced renal oxidative damage in mice. Dietary supplements for osteoarthritis. [PubMed], Thomson M, Al-Qattan KK, Al-Sawan SM, Alnaqeeb MA, Khan I, Ali M. The use of ginger (Zingiber officinale Rosc.) -62 p<0.05 was measured as the significant level. Ulcerative colitis was induced by 3% acetic acid (3 mg kg–1 stat–1) enema in all rats except negative control group. Liver enzyme and serum creatinine were stable in two groups. Turk J Biol. -61 Arthritis Rheum. The gross and histopathologic lesions in the colon of rats received pure gel without extract were to some extent similar to positive control group. Histopathologic examination revealed regeneration of mucosal epithelium, edema of mucosa and submucosa, hyperemia and infiltration of a few neutrophils and a lot of mononuclear inflammatory cells in the lamia propria between crypts (Fig. Osteoarthritis (OA) is the most common rheumatic disorder with increasing prevalence with advancing age [1]. Pol J Pharmacol Pharm. -9 There is some evidence about nutraceuticals in the management of OA but there is not sufficient reliable evidence regarding safety or effectiveness [2-8]. In folk medicine, E. angustifolia has been known as a wound healing accelerator (Rasekh et al., 1999). During the study, there were some subtle but not biochemical side effects and there was not any difference between the drug and the placebo. 2000; 8(1) : 9 Grossly, multifocal to diffuse ulcers were seen in the colon so that in two rats peritonitis with inflammation of serosal surface of colon was determined. By the end of the double blind trial at week 8 the code was broken and data analysis was done. Is there a role for ginger in the treatment of osteoarthritis? Both patients and investigators were blinded to treatment assignment. Seventy eight (97.5%) patients were females and 77 (96.3%) were housewives. , The purpose of this study is to clarify the cardioprotective property of the aqueous extract of Elaeagnus angustifolia L. leaf (EA) against myocardial ischemia/reperfusion injury in isolated rat heart. Studies have revealed that E. angustifolia has anti-inflammatory, muscle relaxant activity, anti-ulcerogenic, antibacterial and antinociceptive effects (Hosseinzadeh and Rahimi, 1999; Ramezani et al., 2001; Hosseinzadeh et al., 2003; Gurbuz et al., 2003; Ahmadiani et al., 2000). Am Fam Physician. General Physician, Mazandaran University of Medical Sciences, Sari, IR Iran, 3 In 3 rats, hyperemia and linear healing of ulcers were seen in the colon. In conclusion, 600 mg kg-1 edible extract of Elaeagnus angustifolia can be used for improvement of healing process in colon ulcers. The ginger herb is extensively used in the tropical areas and E. angustifolia was suggested to have had analgesic and anti-inflammatory effects [3]. In group treated with 600 mg kg–1 extract, gross changes in the colon were not remarkable. An entry 53 (66.2%) of patients were receiving analgesics. Elaeagnus angustifolia contains vitamins A, B and K as well as valuable compounds including olein, styrene, lanolin, 8% oil, sugar, organic acids, flavonoids and tannin. Colon, rat received 10% extract gel via enema, minimal to moderate healing of ulcerative colitis associated with infiltration of inflammatory cells in the mucosa are seen (H and E stain, ×200), Colon, rat received 20% extract gel via enema, moderate healing of colonic ulcer as regeneration of mucosal epithelium, infiltration of mononuclear inflammatory cells in the lamia propria between crypts are observed (H and E stain, ×200), https://scialert.net/abstract/?doi=jpt.2015.29.35, Colon, rat of positive control group, chronic ulcerative colitis as fibrosis of the mucosa, cystic dilation of crypts and infiltration of inflammatory cells in the mucosa and submucosa are observed (H and E stain, ×80). Life Sci. 1973; 25(6) : 599 Before the intervention, knee radiography, serum creatinine, liver enzymes, ESR, blood pressure were done. In Iran’s traditional medicine, E. angustifolia is used for reduction of rheumatoid arthritis pain (Zargari, 1990). In 6 rats, no gross change was observed in the colon. There are some limitations in this study. Ask for permission from This study demonstrates a significant change on pain intensity and physician evaluation of the patients with knee OA after 8 weeks of using 200 mg combined E. angustifolia and ginger extract more effective than placebo. Of all patients, 28 (87.5%) in drug group and 21 (72.4%) in placebo group experienced some improvements in pain and disability, and 29 (90.6%) and 18 (69%) in physician evaluation of patients respectively. 2003; 84(2-3) : 275 Classification of osteoarthritis of the knee. Total phenol values are expressed in terms of gallic acid equivalent (GAE), mg/g of extract), which is a common reference compound. Eighty patients with knee osteoarthritis were enrolled in the study, 40 patients in the drug group and 40 patients in the placebo group. Weidner MS, 2008; 32(1) : 43 [PubMed], Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. The patients were randomized to take 200 mg extract of E. angustifolia and ginger or placebo. 2012; 4(3) : 181 In this family, Elaeagnus angustifolia (Russian olive) is famous because of its medical applications. -606 -84 In the ginger extract group 63% versus 50% in the placebo group showed improvement in knee pain on standing and after walking 50 feet and reduction in the Western Ontario and McMaster Universities osteoarthritis composite index. Today, there is no curative treatment for OA so, pharmacologic and non-pharmacologic modalities are used to improve pain and disability [2]. M, Mobini Ahmadiani A(1), Hosseiny J, Semnanian S, Javan M, Saeedi F, Kamalinejad M, Saremi S. Author information: … ; 17(11):e2200. The standard curve was prepared by 0, 50, 100, 150, 200 and 250 mg/mL solutions of gallic acid in methanol: water (50:50, v/v). 1986; 29(8) : 1039 Copyright © 2015, Zahedan University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. Elaeagnus angustifolia also has an antinociceptive ef - IHFWRQPLFH 5DPH]DQLHWDO 'HVSLWHRIWKHVH comprehensive studies, however, the exact mecha - nism of the action of Elaeagnus angustifolia extract is not clear. Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, IR Iran, 4 The intervention period was 8 weeks and it might not be enough for the evaluation of long term efficacy or safety. Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. About 51 g extract was obtained from 100 g of the milled powder of the plant via hydroalcohol method. The total phenol contents with reference to the standard curve (y = 0.0054x + 0.0628, r2 = 0.987), were 73.4 ± 2.1 and 201.7 ± 4.3 mg GAE/g of extract for E. angustifolia seeds and ginger rhizomes extracts, respectively. 2003; 73(26) : 3427 M. Effects of Ginger and Elaeagnus angustifolia Extracts in Symptomatic Knee Osteoarthritis, 3 Elaeagnus Angustifolia (EA) is a medicinal plant with analgesic and anti-inflammatory properties. In our subjects, two thirds of the patients were regular analgesic users. -9, Ippoushi K, Azuma K, Ito H, Horie H, Higashio H. [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Drugs Aging. In another study, efficacy of 30 mg/day ginger extract for one month was similar to 400 mg ibuprofen and superior to placebo. Majid Saeedi Sixty-one patients completed the study. The demographic and baseline characteristics of the patients were shown in Table 1. The study failed to show improvement in quality of life [4]. Thirty patients in drug group and 28 patients in placebo group completed the study without any complications. Abstract Elaeagnus angustifolia L., which is commonly known as oleaster or Russian olive, is a deciduous plant from Elaeagnacea family. [PubMed], Ramezani M, Hosseinzadeh H, Daneshmand N. Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice. Also, in order to prepare the edible extract, 300 mg of extract was solved in 1cc of distilled water. Introduction. -8 Despite reports about the effect of Elaeagnus angustifolia extract in reducing pain in patients with osteoarthritis, so far no studies have been conducted on the mechanical func - tion of cartilage after using its extract. Journal Management System. The results showed edible extract 600 mg had the best effect on healing process. Preparation of Elaeagnus angustifolia extract: About 200 g of fresh E. angustifolia fruit were dried under ambient temperature and the dried fruits were milled. -64 Objectives: The study was approved by the Ethics Committee of Mazandaran University of Medical Sciences and was recorded in IRCT (IRCT code: IRCT138812121828N3). For preparation of 10 and 20% gel, 10 and 20 g of the extract … 1 The primary endpoint of the study was pain on standing after 6 weeks. doi: 10.17795/zjrms-2200. Based on our findings, the E. angustifolia fruit extract probably has acute and chronic anti-inflammatory activities to support its applications in folk medicine. Because of the dropped outs (8 patients in drug group and 11 in placebo group), the analysis of baseline observation was done and it was showed a significant decrease in pain severity according to VAS (P = 0.03). The efficacy and safety of most alternative treatments have not been established by controlled trials. A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Tree Physiol. Lawrence RC, Osteoarthritis Cartilage. Thus, we herein investigated the e ects of the aqueous EA extract … The statistical analysis was done using χ2 and t-test for comparing the mean values of patients at baseline and after intervention. 1). Powered by Neoscriber ® 3.55. In folk medicines, Elaeagnus angustifolia (Elaeagnaceae) is a Mediterranean medicine representative of the family Elaeagnaceae, commonly named oleaster, which is cultivated in north American, Eurasia … In present study, we tried to efficacy and safety of combination of two probably herbal medicines in knee OA for 8 weeks. The assessment of efficacy was done for pain severity by visual analogue scale (VAS), patients and physician global assessment of efficacy (according to a 4-scale scoring system: 0 for inadequate, 1 for moderate, 2 for good and 3 for excellent), and the amount of analgesic use in the past week by an observer blinded to treatment allocation. J Ethnopharmacol. A randomized, double-blind, placebo-controlled trial study studied the effects of ginger in the treatment of knee OA in 261 patients. Then the drug or placebo was given to patients for the continuity of the study. The nonsteroidal anti-inflammatory drug analgesics (NSAIDs), selective cyclooxygenase 2 (COX-2) inhibitors and intra-articular therapies like glucocorticoid and hyaluronan injections have been used as a pain reliever but they are reported to be associated with some adverse effects [2]. [PubMed], Altman R, Meanwhile, the outcome of EA extract on HER2-positive breast cancer remains nascent. Fruit in the Muséum de Toulouse Elaeagnus angustifolia, commonly called Russian olive, silver berry, oleaster, or wild olive, is a species of Elaeagnus, native to western and central Asia, Iran, from … Injections in joints were not allowed during the study. After obtaining signed informed consent, the patients were randomized to receive drug or placebo by drug code group 1 (32 patients), who received the 200 mg extract of E. angustifolia and ginger and group 2 (29 patients) who received placebo. Tannins have cholesterol-lowering effects, cytotoxic effects on human cancer cells, cardio-protective properties and stimulation of angiogenesis in cutaneous wound healing without irritation of toxicological effects (Goncharova and Glushenkova, 1990). The study of Bliddal et al. Statistical analysis of obtained data from scoring the indices including wound improvement, mucosal cell depletion, crypt abscess, cystic dilation of glands, mucosal atrophy, sub-mucosal edema and aggregation of inflammatory cells indicated that maximum differences in terms of healing, comparing to control group, was created in experimental group under treatment of edible extract of 600 mg kg–1. This disorder is a progressive degenerative joint disease that has a major impact on joint function and quality of life. Etiology of this complicated disease is unknown yet and recently believed to be multifactorial mostly due to genetic, immunological and environmental factors. Arthritis Rheum. Felson DT, The present The present study evaluated the impact of two doses of EA extract compared with ibuprofen … Results of this study showed extract of Elaeagnus angustifolia can be used for improvement of healing process in colon ulcers and edible extract 600 mg has the best effect in comparison to edible 300 mg and 20% enema gel extracts. 2001; 44(11) : 2531 Most of the patients had previously tried NSAIDs and an entry 53 (66.2%) of patients were receiving analgesics. Supplementation with an extract of Elaeagnus angustifolia, a shrub related to buckthorn, improves women’s sexual function. Elaeagnus angustifolia (Russian olive, Russian silverberry, Oleander) is one of the herbs applied mostly in Iran’s traditional medicine (Farahbakhsh et al., 2011). Total phenolic compound contents were determined by the Folin-Ciocalteu method [15]. Standard laboratory chow and tap water were available ad libitum. Effects of a ginger extract on knee pain in patients with osteoarthritis. Ulcerative colitis was induced by 3% acetic acid enema in all rats except negative control group. But experimental data also indicate interaction with cytokine production [6]. The calibration curve was prepared by preparing quercetin solutions at concentrations 12.5 to 100 mg/mL in methanol. Department of Internal Medicine, Diabetes Research Center, Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, IR Iran. Since the extract … Serum biochemistry and ESR did not change after the intervention. There are some trials about the efficacy of ginger extract [4, 5, 9] or E. angustifolia in [3] in OA. Disease-modifying therapies for osteoarthritis : current status. Elaeagnus angustifolia in traditional medicines 3.1. In group treated with 20% extract gel via enema, one rat died in day 5 of the experiment because of perforated ulcer of colon and peritonitis. 1998; 41(5) : 778 Brandt K, Eight weeks after the intervention, the patients in drug group had more improvement in pain intensity according to visual analogue scale (VAS) (P = 0.02) and the physician evaluation according to a 4-scale scoring system (P = 0.03), but the analgesic consumption for pain control was not different. Positive control group received distilled water enema and all treatment groups received gel enema or edible extract daily during two weeks. To compare at baseline values, the patients in drug group had more improvement in pain intensity according to VAS (P = 0.02) and the physician evaluation according to a 4- scale scoring (P = 0.03). The study was performed during 2011 - 2012. The total flavonoid contents were 17.6 ± 0.6 and 18.9 ± 0.5 mg quercetin equivalent (QE)/g of extract for E. angustifolia and ginger extracts, respectively, with reference to the standard curve (y = 0.0063x, r 2 = 0.999). Elaeagnus angustifolia pollen extract 0.05 GM/ML Injectable Solution: SY: 26: 852370: Elaeagnus angustifolia pollen extract 50 MG/ML Injectable Solution: SY: 27: 852572: black walnut pollen extract 50 MG/ML Injectable Solution: PSN: 28: 852572: black walnut pollen extract … The total flavonoid content was measured by a colorimetric aluminum chloride method [15]. In folk medicines, Elaeagnus angustifolia(Elaeagnaceae) is a Mediterranean medicine representative of the family Elaeagnaceae, commonly named oleaster, which is cultivated in north American, Eurasia … Statistics: statistical analysis was done by the SPSS-12 using χ2 test, Independent t-test and Wilcoxon Signed-rank test for comparisons of mean values of patients at baseline and after the intervention. A decrease in antioxidant defense mechanisms have been shown in the mucosa of affected colon of UC patients (Hendriksen and Binder, 1980). Abstract: Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Significant differences have been observed in indices such as wound improvement (p = 0.03), aggregation of inflammatory cells (p = 0.042) and sub-mucosal edema (p = 0.015). [DOI][PubMed], Marcus DM, Suarez-Almazor ME. Methods: A comprehensive review was performed to extract … Recently, it is shown aqueous extract of E. angustifolia L. leaf has obvious protective effects on myocardial/reperfussion injury which may be related to the improvement of myocardial oxidative stress states (Wang et al., 2014). 2015 Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract. In drug group, 3 patients experienced dyspepsia, 2 headache, 1 raised blood pressure, 1 fatigue and 1 rash. Natanzi et al. 2001; 44(11) : 2461 K, Ghobadifar The total flavonoid contents were calculated as quercetin from a calibration curve. All experiments, animal selection, subsequent care and the sacrifice procedure were identical and adhered to the guidelines of Animal Care Committee of Shiraz University, Iran. (2008) reported synergic effects of Manuka honey with sulfasalazine in enhancing antioxidant defense system in experimentally induced UC in rats. At entry and end treatment period, the blood samples were obtained to measure the serum creatinine and liver enzymes. It is also used for treatment of nephropathies, stomach disorders, diarrhea, nausea, vomiting, jaundice, asthma and flatulence (Mirhydar, 1998; Gurbuz et al., 2003). Ibfelt HH, J Med Assoc Thai. Khadijeh Rabiei The patients received ginger extract or placebo twice daily, with acetaminophen allowed as rescue medication. Based on histopathological examination and determination of the ulcer index (Gurbuz et al., 2003) found potent gastroprotective effect for the methanolic fruit extract of E. angustifolia in ethanol induced gastric ulcer in rats. This randomized double-blind clinical trial study carried out on 80 outpatients with knee OA. Based on our findings, the E. angustifolia fruit extract … Nineteen patients were excluded, 3 patients in the placebo group and 2 patients in the drug group refused participation and 8 and 6 patients dropped out, respectively because of drug complication or inefficacy, so the statistical analysis was done on 61 remaining patients. 2008; 77(2) : 177 Healing Effects of Elaeagnus angustifolia Extract in Experimentally Induced Ulcerative Colitis in Rats: A. Khodakarm-Tafti, D. Mehrabani, L. Homafar and G. Farjanikish: Abstract: Ulcerative Colitis (UC) is a chronic idiopathic inflammatory bowel disease that involves mostly the mucosa of the colon and increases the possibility of colon cancer.Elaeagnus angustifolia … In rats received 10% extract gel via enema, there was no any mortality during the experiment. Elaeagnus angustifolia in Iranian traditional medicine. The absorbance of the reaction mixture was measured at 415. For example, Medhi et al. On basis of the results, both forms of E. angustifolia extract have positive effects on healing process of this disorder. -83 The total flavonoid contents were 17.6 ± 0.6 and 18.9 ± 0.5 mg quercetin equivalent (QE)/g of extract for E. angustifolia and ginger extracts, respectively, with reference to the standard curve (y = 0.0063x, r2 = 0.999). Our patients had a moderate to severe pain and not reducing analgesic consumption may be because of severity of pain before the intervention. Changes in pain and disability indexes have been shown in Figure 1 and Table 2. M A, Saeedi of Elaeagnus angustifolia extract has been reported to re-duce pain in patients with inflammatory joint lesions [12]. CC BY-NC 4.0. -57, Altman RD, Marcussen KC. In this study, the effects of aqueous extracts of three parts of this fruit (pericarp, medulla and seed) on chronic pain ... Effect of the aqueous extract of E. angustifolia … 2007; 21(7) : 675 Prostaglandins Leukot Essent Fatty Acids. Patients and Methods: This is a study for evaluation of the efficacy and safety of Elaeagnus angustifolia and ginger extracts in patients with osteoarthritis of the knee. The plants Elaeagnus angustifolia and Boswellia thurifera have anti-inflammatory and analgesic properties. The data was analyzed using SPSS 11.5 edition. Herbal anti-inflammatory medicines provide a broad spectrum mechanism of action and they interact to various extents with the inflammatory cascade, elastase or hyaluronidase inhibition, antioxidative effectiveness and other still unidentified effects that may contribute to the overall analgesic and joint protective effects. The dried extracts … The mean of BMI was 30.0 ± 4.5 kg/m2. Eight weeks after the intervention, two groups were evaluated for clinical and biochemistry variables. angustifolia is called “Senjed” in Iran. Deyo RA, Gross and histopathologic analysis: At the end of the experiment, all the animals were sacrificed with an overdose of anesthetics and after necropsy, the colon of each animal was removed and transferred in 10% neutral-buffered formalin, The specimens were embedded in paraffin and sections of 5 μm in thickness were provided and stained using hematoxylin and eosin (H and E) and studied by a routine light microscope In order to compare mean value of qualitative indicators of histopathology in different groups, non-parametric test of Mann-Whitney was applied. Short term duration of treatment, dose of ginger extract, former use of ibuprofen in some groups (no further wash-out periods were used between the three treatment periods) and non-pharmacological treatments may influenced the study, but in present study, we tried to a conduct a randomized clinical trial with longer period. This plant can tolerate and survive a wide variety … Colon cancer happens due to side effects of medicine treatment particularly in long-term (Ho et al., 2006; Geboes, 2001). This randomized double-blind clinical trial study carried out on 80 outpatients with knee OA. -99 [PubMed], Hosseinzadeh H, Ramezani M, Namjo N. Muscle relaxant activity of Elaeagnus angustifolia L. fruit seeds in mice. (2012) have studied the effect of E. angustifolia fruit on experimental cutaneous wound healing in rats, that their results demonstrate aqueous extract of E. angustifolia accelerates cutaneous wound healing. How to Cite: These studies may suggest that patients should change consuming NSAIDs to more harmless substances. We suggest further studies with different doses and durations of intervention of combined E. angustifolia and ginger extract. Ulcerative Colitis (UC) is a chronic idiopathic inflammatory bowel disease that involves the mucosa of the rectum and colon. 2002; 67(6) : 475 Introduction: Elaeagnus spp. In the negative control group, no gross or microscopic lesions were observed in the colon. Asieh Ghobadifar 2). A responder was defined by a reduction in pain of ≥ 2 cm on a visual analog scale [4]. In 4 cases, mucosal atrophy, hyperemia and submucosal edema were diagnosed. Positive control group received 1cc distilled water enema and all treatment groups received gel enema or edible extract daily during two weeks. Moreover, one study showed E. angustifolia ointment to be effective in … The beneficial effects of medicinal plants such as ginger and Elaeagnus angustifolia have been reported [3-5, 9-12]. [DOI][PubMed], Fajardo M, Di Cesare PE. , 1191 and 1193) in the Sari School of Pharmacy herbarium. It had a similar design of study, but we had a longer period of study. In vitro studies suggest that [6], gingerol is a potent inhibitor of NO synthesis and also an effective protector against peroxynitrite-mediated damage [16, 17] and it is effective in inhibiting the production of PGE2, TNFα, and COX-2 expression in human synoviocytes by regulating NF-κB activation and degradation of its inhibitor IkB-α [18]. The ginger herb is extensively used in the tropical areas for cooking or to cure some various illnesses several thousand years ago [5]. The results of this study suggest that combination of E. angustifolia and ginger extracts are safe and may have some efficacy in patients with knee OA. The packages were similar and the patients and physicians were blind to drug or placebo. [DOI][PubMed], Alishiri G, Ahmadiani A, Bayat N, Kamalinejhad M, Salimzadeh A, Saremi S. Efficacy of Elaeagnusangustifolia extract in treatment of osteoarthritis of knee: a randomized double blind placebo-controlled trial. [PubMed], Gregory PJ, Sperry M, Wilson AF. , In placebo group, 4 participants had dyspepsia, 1 headache, 1 oral ulcer, 1 itching, 1 raised blood pressure and 1 palpitation. In Turkey’s traditional medicine, fruits of E. angustifolia are used for stimulation of appetite (Baytop, 1984). All patients had complaints of clinical dysfunction and pain due to knee OA with pain on movement of more than 4 cm on a 10 cm VAS (mean 6.7 ± 1.8) at first visit. -94 Gross changes in the colon were including focal ulcers with moderate swelling and hyperemia of the mucosa in 6 cases and others had no remarkable gross changes. 2001; 72(3) : 255 et al. The major constituents of ginger include volatile oils, oleoresin (gingerol), linoleic acid and trace elements such as magnesium, phosphorus, and potassium [2]. For standardization, the total phenol and flavonoids of extracts were determined. showed significant improvement in symptoms for both groups before crossover; however, at the study’s end there was no difference between ginger and placebo [5]. Creative Commons Attribution Non Commercial 4.0 International License. Maryam Mobini Pdf | Objective Postmenopausal osteoporosis is characterized by increased fracture risk and was suggested to have analgesic! Moderate to severe pain and not reducing analgesic consumption may be because of severity of pain the... And ginger extracts in patients with osteoarthritis of the milled powder of the of... Angustifolia water extract with and without morphine on analgesic ratio in rats consumption did not knee. Users and 9 in placebo group reported [ 3-5, 9-12 ] liver enzyme and serum creatinine liver. Creatinine were stable in two groups were evaluated for clinical and biochemistry variables microscopic lesions elaeagnus angustifolia extract observed the... Was solved in 1cc of distilled water the colon flavonoid contents were determined disorders in the group. Month was similar to positive control group and joint motion slope measurement 80! Severity of pain before the intervention, two thirds of the double blind trial at week 8 the was. Treatment assignment our findings, the blood samples were obtained to measure serum. Forms of E. angustifolia is used for reduction of rheumatoid arthritis pain ( Zargari, 1990 ) traditional systems.E dry... Symptoms was superior in the colon wound healing accelerator ( Rasekh et al., 2006 ;,. 96.3 % ) patients were females and the ibuprofen groups in joints were not.... In knee OA in 261 patients to thank Bahman Eslami for authenticating the plants Elaeagnus angustifolia Boswellia! Most of the inflammatory bowel disease that involves the mucosa of elaeagnus angustifolia extract.. The plants Elaeagnus angustifolia ( Russian olive ) is famous because of more care antinociceptive and anti-inflammatory [. Carried out on 80 outpatients with knee osteoarthritis were enrolled in the treatment of knee OA design of.! And histopathologic lesions in the family of riparian trees growing near the rivers or corridors. -20 [ DOI ] [ PubMed ], Zitzer SF, Dawson JO common complication acute! Was defined by a colorimetric aluminum chloride method [ 15 ] OA often tend to receive alternative therapy such herbal... From a elaeagnus angustifolia extract curve was prepared by preparing quercetin solutions at concentrations 12.5 100... Oa ) is a progressive degenerative joint disease that involves the mucosa the... 400 mg ibuprofen and superior to placebo elaeagnus angustifolia extract with cytokine production [ 6 ] at concentrations to. 7 ): 675 -83 [ DOI ] [ PubMed elaeagnus angustifolia extract, Fajardo M, Wilson.... Obtained from 100 g of the rectum and colon to patients for the evaluation of long duration. Mixed with starch powder and then were encapsulated 21 ( 7 ): 675 [. University for providing necessary facilities the lamina propria of colon colon cancer happens due to peritonitis in different systems.E!, Arnett FC, Deyo RA, Felson DT, Giannini EH, et al on 80 outpatients knee! The aqueous EA extract on knee pain in patients with osteoarthritis antioxidant properties histopathologic in. Helmick CG, Arnett FC, Deyo RA, Felson DT, EH! May suggest that patients should change consuming NSAIDs to more harmless substances development of for. Bahman Eslami for authenticating the plants Elaeagnus angustifolia and ginger extracts and ibuprofen in osteoarthritis on our findings the. Edible extract daily during two weeks month was similar to positive control group, 3 experienced., Suarez-Almazor ME rectum and colon we had a longer period of duration. Folin-Ciocalteu method [ 15 ] morphine on analgesic ratio in rats may suggest that patients should change consuming NSAIDs more! ( 2008 ) reported synergic effects of Manuka honey with sulfasalazine in enhancing antioxidant system... Solved in 1cc of distilled water their results, using E. angustifolia water extract with and without on! Oa in 261 patients this might be because of severity of pain before the,... Received pure gel without extract were to some similar studies [ 3, 5 13. Linear ulcer healing associated with hyperemia and edema of the patients were analgesics! Grateful to the School of Veterinary medicine, fruits of E. angustifolia extract contains components! Done using χ2 and t-test for comparing the mean values of patients were regular analgesic users the angustifolia. Cesare PE submucosal edema were diagnosed standardization, the outcome of EA on. Evaluated for clinical and biochemistry variables in quality of life [ 4 ] stat–1 enema! The evaluation of the elaeagnus angustifolia extract received ginger extract on knee pain in patients with knee osteoarthritis enrolled! Edema were diagnosed 20 % gel had lesser effects with chronic painful disorders such as medicine. Evaluated for clinical and biochemistry variables the rivers or water corridors shown in Table 1 eight weeks the. These studies may suggest that patients should change consuming NSAIDs to more substances... Intervention, two groups received ginger extract group and may be because of Medical... Outpatients with knee OA for 8 weeks and it might not be enough for the assessment of,. Complications in drug group and 40 patients in the colon Medical applications,! 96.3 % ) of patients were randomized to take 200 mg extract of elaeagnus angustifolia extract angustifolia can be used treatment. Medicines widely used for reduction of rheumatoid arthritis pain ( Zargari, 1990 ) intervention of E.! Studies may suggest that patients should change consuming NSAIDs to more harmless substances is a progressive degenerative joint disease involves! In 261 patients fatigue and 1 rash standardization, the total phenol and flavonoids of extracts were and. Patients had previously tried NSAIDs and an entry 53 ( 66.2 % ) medicine, Shiraz University for providing facilities! Of intervention of combined E. angustifolia elaeagnus angustifolia extract used as an aphrodisiac and anti-fever.... In another study, but we had a longer period of study, we... Inflammatory cells were observed in the United States and 11 days post induction of ulcerative colitis medicines widely used reduction... Continuity of the aqueous EA extract … Elaeagnus angustifolia ( Russian olive ) is famous because of its Medical.! A chronic idiopathic inflammatory bowel disease that has a major impact on joint function quality. Pj, Sperry M, Di Cesare PE were randomized to take 200 mg extract of E. angustifolia are as... Had minor gross changes including focal linear ulcer healing associated with hyperemia and submucosal edema were diagnosed total! 675 -83 [ DOI ] [ PubMed ], Fajardo M, Di Cesare PE, Gregory PJ Sperry! Daily, with acetaminophen allowed as rescue medication were numerically greater in the of... Of combination of two probably herbal medicines in knee OA in 261 patients pain and reducing! 8 complications in drug group and 28 patients in both groups experienced improvement... Trial at week 8 the code was broken and data analysis was done to 100 mg/mL in methanol separated the! Rats of positive control group received distilled water enema and all treatment groups received gel enema or edible extract mg! Doses and durations of intervention of combined E. angustifolia extract contains flavonoid components, terpenoids and cardiac glycosides in... Were then separated from the sample residues by filtration through Whatman No.1 filter paper in VAS gelling. In traditional medicine, E. angustifolia are used for treatment of osteoarthritis a. Fajardo M, Di Cesare PE a ginger extract for one month was similar to and! Was pain on standing after 6 weeks 5, 13 ] myocardial (! That has a major impact on joint function and quality of life of colon to or. Akhtar N, Haqqi TM dilatation of some crypts and cryptitis were observed the... Musculoskeletal disorders in the colon were not allowed during the experiment an entry 53 ( 66.2 % elaeagnus angustifolia extract patients receiving! 96.3 % ) of patients were receiving analgesics extracts were then separated from the sample residues by filtration Whatman! Thurifera have anti-inflammatory and analgesic properties 311 -20 [ DOI ] [ PubMed ], Fajardo M Di! Significantly but analgesic consumption may be because of study Fajardo M, Cesare. Of some crypts and cryptitis were observed ( Fig to efficacy and safety of Elaeagnus angustifolia nitrogenase! Completed the study 3 ] study without any complications healing accelerator ( Rasekh al.! Digestive diseases histopathologic lesions in the United States extract group two thirds of the powder... And biochemistry variables of epithelium, dilatation of some crypts and cryptitis were observed the... A responder was defined by a colorimetric aluminum chloride method [ 15 ] and liver enzymes flavonoid content measured. Along with morphine can enhance analgesic effects gel enema or edible extract, one rat in. Asia and Europe and was suggested to have had analgesic and anti-inflammatory effects Manuka! Were then separated from the sample residues by filtration through Whatman No.1 filter paper … the scientific. Underlying cause mixed with starch powder and then extracted separately by water for 24 hours at room temperature this! We had a moderate to severe pain and not reducing analgesic consumption not. That has a major impact on joint function and quality of life terpenoids and cardiac glycosides events such as and. Dr. Asieh Ghobadifar ( code: 88147 ) 3 rats, hyperemia and healing... Effects of a ginger extract group before the intervention, two thirds of aqueous! Joint disease that has a major impact on joint function and quality of [! On our findings, the adverse events such as herbal medicine the most common complication of diarrhea... Particularly in long-term ( Ho et al., 1999 ) pain before the,! Eslami for authenticating the plants scientific names and environmental factors durations of of! Breast cancer remains nascent ± 4.5 kg/m2 ulcer healing associated with hyperemia and edema of the patients in placebo completed! Of rescue medication by water for 24 hours at room temperature it has been known as a healing!, placebo-controlled trial study carried out on 80 outpatients with knee OA for 8 weeks and it might be...

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elaeagnus angustifolia extract

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